Signalling Oxidative Stress in Saccharomyces cerevisiae

Abstract

Mitochondrial oxidation appears to be a major cause of signalling to different pathways; however it is still unclear which one of the inflammatory or the apoptotic signals plays a more relevant role in the mitochondrial generation of ROS. Starvation can increase ROS steady-state concentration and autophagy. Hydrogen peroxide appears to be the major oxidant in these conditions, and would oxidise specific cysteines in autophagyc genes leading to the increase in the autophagosome formation. However it is unknown how the signal is transduced to specific targets (Reviewed in Finkel, 2011).