Successful treatment of septic shock due to N ew D elhi metallo‐β‐lactamase‐1‐producing K lebsiella pneumoniae in a patient transferred from I ndia to J apan

Abstract

CASE: Here we report the fifth case of New Delhi metallo-β-lactamase-1-producing Enterobacteriaceae infection in Japan. A 39-year-old Japanese man suffered a subarachnoid hemorrhage due to rupture of aneurysm in India. Once he was deemed stable enough, he was transferred from a hospital in India to our hospital in Japan. On day 5 after transfer, the patient suddenly developed septic shock and multidrug-resistant Klebsiella pneumoniae was isolated from a blood culture. OUTCOME: Treatment with colistin and high-dose meropenem as well as organ support were initiated, resulting in successful resolution of septic shock. This K. pneumoniae was shown to carry bla(NDM)(-1) by polymerase chain reaction analysis. CONCLUSION: Our case suggests that New Delhi metallo-β-lactamase-1-producing bacteria could be introduced into Japan easily. It is important to apply strict surveillance and infection control measures to prevent the spread of carbapenem resistance genes to Enterobacteriaceae in Japan.