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Diagnostic implications of inconsistent results obtained with the Xpert MTB/Rif assay in detection of Mycobacterium tuberculosis isolates with an rpoB mutation associated with low-level rifampin resistance

Journal of Clinical Microbiology (2013) 51(9) 3127-3129
DOI: 10.1128/JCM.01377-13
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Abstract

Xpert-MTB/Rif is one of the most frequently used molecular screening tests for multidrug-resistant tuberculosis worldwide. We report false-negative assay results in the presence of rpoB Leu533Pro, which is associated with low-level phenotypic rifampin resistance. Accurate and timely confirmation of rifampin susceptibility results obtained with Xpert-MTB/Rif is imperative. Copyright © 2013, American Society for Microbiology. All Rights Reserved.

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Somoskovi, A., Deggim, V., Ciardo, D., & Bloemberg, G. V. (2013). Diagnostic implications of inconsistent results obtained with the Xpert MTB/Rif assay in detection of Mycobacterium tuberculosis isolates with an rpoB mutation associated with low-level rifampin resistance. Journal of Clinical Microbiology, 51(9), 3127–3129. https://doi.org/10.1128/JCM.01377-13

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