THE COMPARISON OF ELEVATED LEVELS OF EBV IMMUNOGLOBULIN A EARLY ANTIGEN BETWEEN NASOPHARYNGEAL CARCINOMA WHO TYPE 3 WITH MALIGNANT NON-HODGKIN LYMPHOMA

Abstract

Introduction: Epstein Barr Virus (EBV) replicate in the epithelial cells and becomes latent in lymphocytes B. This virus is also associated with NPC, NHL, infectious mononucleosis and Burkitt’s lymphoma. The expression product of EBV acute infections can interact with genes in the epithelial cells to start the molecular level that leads to malignancy so that an increase in levels of IgA antibodies EA can indicate high levels of EBV infection. Objective: Comparing the level of IgA EA antibody for EBV between NPC WHO type III  and NHL. Method: Observational comparative analytic method with cross-sectional study design. The subject of this study are 16 NPC patients and 16 NHL patients, consists of 9 males and 7 females. Numeric data of IgA EA calculated by Mann Whitney and the categoric data is calculated by Kolmogorov Smirnov.  The examination of IgA EA level in EBV using ELISA method, with p-value <0.05. Result: This study reveals that there were increasing IgA EA levels in NPC patients (3.71±2.36) compared to NHL (0.27±0.20). There is a difference value of IgA EA in study groups both numerical and categorical. Conclusion: The level of IgA EA EBV antibody in NPC is higher than NHL.