Bi 2 O 3 /1-butyl-1-methylpyrrolidinium bis (trifluoromethane sulfonyl) imide glassy carbon platform: strategy for the electrocatalytic ultrasensitive quantification of multianalytes

Abstract

In the present communication studies on glassy carbon electrode (GCE), modified with Bi 2 O 3 metal oxide and 1-butyl-1-methylpyrrolidinium bis (trifluoromethane sulfonyl) imide ionic liquid (IL) (Bi 2 O 3 /IL/GC), sensor for the voltammetric investigation of ethamsylate (ETA) and mefenamic acid (MEF) simultaneously has been incorporated. The developed sensor was characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). All the analytical parameters were also examined during the electrochemical measurements of these compounds and experimental conditions were optimized. The chemically modified sensor exhibited two well-resolved oxidation peaks at 0.54 and 0.79 V for ETA and MEF, respectively, in phosphate buffer pH 2.0. A good linear response was achieved within the concentration range from 15 to 105 nM for ETA and 1 to 7 nM for MEF. The limit of detection (LOD) for ETA was 6.3 nM and for MEF was 0.4 nM, and limit of quantification (LOQ) for ETA and MEF was 19 nM and 1.2 nM respectively. The developed sensor could be applied to quantify the concentrations of both the compounds in pharmaceutical formulation and human serum sample with satisfactory results.