Interleukin-15 as a potential regulator of the innate immune response

Abstract

Interleukin-15 (IL-15) is a newly-discovered cytokine that is produced by activated monocytes early in the course of the innate immune response. IL-15 is able to bind to components of the interleukin-2 receptor (IL-2R) despite the fact that it has no sequence homology with IL-2. IL-15 stimulates human natural killer cell proliferation, cytotoxicity, and cytokine production and can substitute for IL-2 under most conditions. In vitro studies indicate that monocyte-derived IL-15 may be an important determinant of IFN-gamma production by NK cells. In addition, IL-15 is able to promote the survival of natural killer cells under serum-free conditions. The IL-15 receptor is a heterotrimeric complex which is composed of the IL-2Rβ and γ chains in combination with a unique alpha chain (IL-15α). The IL-15Rα chain has strong sequence homology to the IL-2Rα chain and confers high affinity binding to the IL-15R. In contrast to IL-2, transcript for IL-15 and IL-15α is expressed in a number of tissues and indicates that IL-15 may be an important ligand for cells that express components of the IL-2R.