Derivatives of Hydroxylaniine: Central Nervous System Stimulants

Abstract

A number of O-alkyl substituted hydroxylamine derivatives have been made which are chemically related to the antidepressive agents, iproniazid and β-phenylisopropylhydrazine. These hydroxylamine derivatives, except N-methoxynicotinamide, are not monoamine oxidase inhibitors as are the corresponding hydrazine derivatives. The N-alkoxy-N-(2-phenyl)-isopropylamines acted as stimulants of activity, in both mice and rats, as do amphetamine and β-phenylisopropylhydrazine.3,4 Unlike the corresponding hydrazine derivative, phenethylhydrazine,4 the hydroxylamine derivatives, N-methoxy-N-(2-phenyl)-ethylamine, β-phenylethoxyamine and 3,4,5-trimethoxy-β-phenylethoxyamine, did not appear to stimulate the central nervous system of either mice or rats. © 1961, American Chemical Society. All rights reserved.