A shattering experience

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Abstract

Tang et al. (2022) report that the DNA breaks that provoke chromothripsis—the pulverization and dramatic assembly into a rearranged chromosome—are generated by the base excision repair APE1 endonuclease, triggered by removing deoxyinosines that are created in DNA::RNA hybrids.

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APA

Haber, J. E. (2022, July 7). A shattering experience. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2022.06.018

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