A case of Bufferin® induced acute interstitial nephritis - Adding to analysis of immune cells, cytokine -

Abstract

This paper describes a case report of acute interstitial nephritis associated with Bufferin®. A 15-year-old girl were referred to our hospital due to fever and renal dysfunction. Laboratory findings showed elevation of serum BUN and creatinine, and increased urinary 8-MG excreation. Light microscopic findings of her renal biopsy specimen revealed edema and numerous inflammatory cells in the interstitium, and minor alterations in glomeruli. The interstitial infiltrates consisted mainly of T cells and also monocytes/macrophages. Interstitial cells were labelled with antibodies to interleukin (IL)-l and tumor necrose factor (TNF). Bufferin® was positive by lymphocyte stimulation test. Thus, we considered that this drug was causative in this case. This observation suggests the participation of cell-mediated immune injury in drug induced acute interstitial nephritis. © 1992, Japanese Society of Nephrology. All rights reserved.