Efek Protektif Jus Buah Nanas (Ananas Comosus (l.) Merr.) Terhadap Kadar Enzim SGOT dan SGPT Mencit (Mus Musculus L) Jantan Yang Dipapari Tuak Lokal Lombok

Abstract

Traditional alcoholic drinks are made traditionally or conventionally and simply packed. One of the traditional alcoholic drinks in Indonesia and commonly consumed is Tuak (Palm wine). Several indigenous communities in Lombok have fermented drinks popularly known as Tuak or Arak. Palm sap which is the basic ingredient in making palm wine containing alcohol. The most common liver diseases due to alcohol abuse include fatty liver, alcoholic hepatitis and liver cirrhosis. Ethanol metabolism in liver cells can cause an increase in the production of free radicals with various mechanisms so that oxidative stress will damage liver tissue. The supply of pineapple can prevent and repair liver damage due to oxidative stress processes, especially those caused by alcohol. Markers of liver damage are SGOT and SGPT enzymes. This research is a true experiment. The total number of experimental animals used was 21 individuals, negative control rats were only given standard feed, positive control rats were given palm wine without pineapple extract and treatment group were given palm wine and pineapple extract. Palm wine and pineapple were given together with standard feed for 14 days and on day 15th, the blood of the rats was taken to check the levels of SGOT and blood SGPT. The results showed the average SGOT enzyme levels in the negative control group 117.85 U / L, in the positive control group 126.14 U / L, and the treatment group 110.71 U / L. ANOVA test shows SGOT levels of white rats have significant differences in the experiments conducted (p <0.05). Examination of SGPT enzyme levels in the negative control group obtained an average yield of 25.42 U / L, positive control 30.42 U / L, and treatment 29.14 U / L. The ANOVA test results of SGPT levels in white rats show significant differences in the experiments conducted (p <0.05).