Simultaneous dissolution of naproxen and flurbiprofen from a novel ternary γ-cyclodextrin complex

Abstract

A crystalline ternary complex was prepared by sealed-heating of naproxen (NPX) with a flurbiprofen (FBP)/γ-cyclodextrin (γ-CD) inclusion complex. The dissolution rates of NPX and FBP in the ternary complex were almost the same, indicating that FBP and NPX from the complex dissolved simultaneously. The ternary CD complex showing a fascinating dissolution property could be a new formulation for combination therapies. © 2010 Pharmaceutical Society of Japan.