Do antidepressants work? Statistical significance versus clinical benefits

Abstract

Ours has been called the Prozac generation but, earlier this year, newspaper front page headlines screamed "Antidepressants don't work". Our authors' reanalysis of drug trials was widely reported as implying that antidepressant drugs such as Prozac are overprescribed and useless. The truth, as Blair T. Johnson and Irving Kirsch explain, is more complex, and more interesting. © 2008 The Royal Statistical Society.