How Structural Biologists and the Protein Data Bank Contributed to Recent FDA New Drug Approvals

Abstract

Discovery/development of 210 new molecular entities (NMEs; new drugs) approved by the US Food and Drug Administration 2010–2016 was facilitated by open access to 3D structures stored in the PDB. Nearly 6,000 relevant PDB structures contributed to approval of 88% of these NMEs across all therapeutic areas.