To study the correlation of embryo and oocyte quality with clinical pregnancy rate

Abstract

Background: Embryo and oocyte grading or scoring is the selection and classification of embryo and oocyte according to its quality. Embryo quality is an important factor for successful delivery. It is a non-invasive method of embryo evaluation. It is an easy assessment of embryo without any harm which includes morphological observation. A well morphologically graded oocyte improves the quality of the embryo. Objectives: This study aims to use a standard grading system for better morphological assessment of oocytes and embryos. Eventually, the correlation of oocyte and embryo quality with pregnancy outcome will be determined. Methodology: This non-invasive methodology includes the recording of treatment history and the indications. Counselling of the participants for research will be done. The further protocol includes the morphological assessment of oocyte as well as an embryo by grading system (Gardner) and β hCG level will be evaluated. Expected Results: 50 women will be included. Embryo and oocyte grading system by Gardner will be used for morphological analysis of embryos at cleavage as well as at blastocyst stage according to the day of transfer. Gardner oocyte grading/scor-ing system may predict the selection of best oocyte for IVF/ICSI. Further Gardner embryo grading system may predict the best morphological evaluation of embryo and eventually selection of best quality embryo for transfer. Thus by using the above grading method for selection of embryo for transfer, implantation and clinical pregnancy rate may increase.