Abstract
The best of both worlds: C5-functionalized locked nucleic acids (LNAs) synergistically combine the beneficial features of C5-alkynyl DNAs and conventional antisense LNA - they are straightforward to make and yet exhibit unparalleled thermal affinity toward RNA targets, extraordinary discrimination of singly mismatched RNA strands, and superb stability against degradation by 3′-exonucleases. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
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Østergaard, M. E., Kumar, P., Baral, B., Raible, D. J., Kumar, T. S., Anderson, B. A., … Hrdlicka, P. J. (2009). C5-functionalized LNA: Unparalleled hybridization properties and enzymatic stability. ChemBioChem, 10(17), 2740–2743. https://doi.org/10.1002/cbic.200900500
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