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Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease

  • Roney C
  • Arora V
  • Kulkarni P
  • et al.
International Journal of Alzheimer's Disease (2009) 2009 1-8
DOI: 10.4061/2009/481031
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Abstract

Detecting aggregated amyloid peptides (A β plaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity I 125 -clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) as in vivo probes. I 125 -CQ-PBCA NPs crossed the BBB ( 2.3 ± 0.9 ID/g) ( P

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Roney, C. A., Arora, V., Kulkarni, P. V., Antich, P. P., & Bonte, F. J. (2009). Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer’s Disease. International Journal of Alzheimer’s Disease, 2009, 1–8. https://doi.org/10.4061/2009/481031

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