Abstract
The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin. © 2005 Elsevier Ltd. All rights reserved.
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Vallejos, G., Fierro, A., Rezende, M. C., Sepúlveda-Boza, S., & Reyes-Parada, M. (2005). Heteroarylisopropylamines as MAO inhibitors. Bioorganic and Medicinal Chemistry, 13(14), 4450–4457. https://doi.org/10.1016/j.bmc.2005.04.045
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