Identification of the HNA-3a antigen

Abstract

In this issue of Blood, Curtis et al identify the human neutrophil antigen 3a (HNA-3a), which is contained within the choline transporter-like protein-2.1 Antibodies to HNA-3a have been implicated in significant numbers of fatal TRALI reactions, and the discovery reported by Curtis et al will lead to the identification of HNA-3a-negative donors to make transfusions safer.