Stochastic model for cell polarity

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Abstract

Cell polarity refers to the spatial asymmetry of molecules on the cell membrane. Altschuler, Angenent, Wang and Wu have proposed a stochastic model for studying the emergence of polarity in the presence of feedback between molecules. We analyze their model further by representing it as a model of an evolving population with interacting individuals. Under a suitable scaling of parameters, we show that in the infinite population limit we get a Fleming-Viot process. Using well-known results for such processes, we establish that cell polarity is exhibited by the model and also study its dependence on the biological parameters of the model. © Institute of Mathematical Statistics, 2012.

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APA

Gupta, A. (2012). Stochastic model for cell polarity. Annals of Applied Probability, 22(2), 827–859. https://doi.org/10.1214/11-AAP788

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