Differential roles for octanoylated and decanoylated ghrelins in regulating appetite and metabolism

19Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

Since its identification in 1999, ghrelin has been identified in all vertebrate groups. The active core of ghrelin is highly conserved among vertebrates, suggesting its biological activity to be also conserved. In fish, both acylated forms of ghrelin have been identified; however, the ratio of the ghrelin-C8 to ghrelin-C10 is not as great as observed in mammals. In the tilapia (Oreochromis mossambicus), ghrelin-C10 is the major form of ghrelin. Since fish are known to inhabit every ecological niche on earth, studies on fish have provided valuable insight into vertebrate physiology in general; it is likely that understanding the role of both acylated forms of ghrelin, in more detail, in fish will result into novel insights in the biology of ghrelin within vertebrates. In this paper we discuss ghrelin's role in regulating appetite and metabolism in fish, in general, and provide evidence that the two tilapia ghrelins exhibit different biological roles. © 2010 Sara E. Schwandt et al.

Cite

CITATION STYLE

APA

Schwandt, S. E., Peddu, S. C., & Riley, L. G. (2010). Differential roles for octanoylated and decanoylated ghrelins in regulating appetite and metabolism. International Journal of Peptides. https://doi.org/10.1155/2010/275804

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free