Leukæmia-inhibiting properties and L-asparaginase activity of sera from certain south american rodents

Abstract

GUINEA pig serum is known to exert a striking inhibitory effect on certain transplantable leukæmias of the mouse and rat1. Suppression may be seen, not only with long transplanted leukæmias, but also with recently derived spontaneous and radiation-induced leukæmias (preceding communication). Other sera have been tested, but none has shown unequivocal activity1,2. The only rodent other than the guinea pig, the serum of which has been examined and found to be negative, is the rat2. Up to the present time, however, no animal closely related to the guinea pig has been studied. © 1963 Nature Publishing Group.