Reciprocally regulated chromatin association of Cockayne syndrome protein B and p53 protein

Abstract

Background: The Cockayne syndrome chromatin remodeler CSB and p53 physically interact. Results: CSB facilitates p53-chromatin association when p53 levels are low, and p53 inhibits CSB-chromatin association when p53 levels are elevated. Conclusion: Chromatin association of CSB and p53 is reciprocally regulated. Significance: Reciprocal chromatin association may be a mechanism by which CSB and p53 coordinate their activities to regulate a common set of processes. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.