The role of thrombophilia in pregnancy

Abstract

Thromboembolism in pregnancy is a major contributor to pregnancy morbidity and mortality with potentially serious adverse effects for both mother and foetus. This article aims at exploring the impact of both inherited and acquired thrombophilia on pregnancy and to determine the appropriateness of screening for thrombophilia in pregnancy. Moreover, we focused on the principles and criteria for designing future studies and prior power analysis, i.e. determining the required number of patients in order to obtain significant and medically interpretable information.