A concise stereoselective route to the pentacyclic frameworks of arisugacin A and territrem B

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Abstract

A highly efficient and stereoselective formal [3+3] cycloaddition reaction using chiral α,β-unsaturated iminium groups is the key step in producing the advanced frameworks of the natural products arisugacin A and territrem B (see scheme; PG = protecting group).

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Zehnder, L. R., Hsung, R. P., Wang, J., & Golding, G. M. (2000). A concise stereoselective route to the pentacyclic frameworks of arisugacin A and territrem B. Angewandte Chemie - International Edition, 39(21), 3876–3879. https://doi.org/10.1002/1521-3773(20001103)39:21<3876::AID-ANIE3876>3.0.CO;2-C

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