Off the beaten track: The molecular structure of long-term memory: Three novel hypotheses—electrical, chemical and anatomical (allosteric)

Abstract

This opinion paper reviews three hypotheses relating to the possible molecular events involved in the formation of long-term memories that go beyond the classical theory, which is confined to strengthening Hebbian synapses. The aim of this paper is not to write detailed critiques of these three hypotheses but to present, for the first time in one location, their essential components to engage the interest of the reader in these new ventures.