A cobalt-catalyzed sulfonate/copper exchange for the preparation of highly functionalized electron-deficient aryl copper reagents

Abstract

(Chemical Equation Presentation) Organocopper reagents from phenols: A new cobalt-catalyzed aryl sulfonate/ copper exchange reaction allows the synthesis of highly functionalized aryl copper reagents from sulfonates bearing elec-tron-deficient substituents under mild conditions (25-45 °C, 1-6 h; see example). Sensitive functional groups, such as aldehydes, esters, and nitriles, are welltolerated. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.