Synthesis and Docking Study of Pyrimidine Derivatives Scaffold for Anti-Hypertension Application

Abstract

The present work introduces four new macromolecules pyrrolo[2,3-d]pyrimidine scaffolds substituted with various benzene-sulfonamide moieties; those were picked up via cyclization of 2-amino-3-cyanopyrroles with phenyl isothiocyanate. The newly prepared pyrrolopyrimidine derivatives have been elucidated by spectroscopic techniques (FT-IR, 1HNMR, 13CNMR and MS) and elemental analyses. The antihypertensive activity of the synthesized pyrrolopyrimidine derivatives based on sulfonamide moiety was evaluated. All pyrrolopyrimidine derivatives were showed a potent antihypertensive activity than Prazosin that utilized as standard drug. The structure activity relationship (SAR) was studied to correlate the influence of sulfonamide group with the aminopyrimidine moiety. Molecular docking for the synthesized derivatives and theoretical statistics were carried out to expect their antihypertensive efficacy.