Multicomponent C-alkylation reactions of aromatic aldimines with trialkylboranes reagents

Abstract

The one-pot three-component reaction of an aryl aldehyde, an arylamine, and a trialkylborane in the presence of hydrogen peroxide afforded the alkylated arylamines 1 in good yields via oxidized imine-borane complexes. In addition, the versatility of our procedure has been confirmed by the use of enolizable aldehydes, alkylic amines, and cyclic imines. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.