Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

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Abstract

During efforts to prepare the known compound NMDI1, a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.

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Gotham, V. J. B., Hobbs, M. C., Burgin, R., Turton, D., Smythe, C., & Coldham, I. (2016). Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay. Organic and Biomolecular Chemistry, 14(5), 1559–1563. https://doi.org/10.1039/c5ob02482j

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