Morphology of target drug delivery systems (CaCo3 vaterites covered with dextran sulfate) in rat muscular tissue

Abstract

The present work is focused on the study of target drug delivery systems comprised of porous spherical calcium carbonate vaterites (СаСО3 ) covered with the dextran sulfate protective shell. Behavior of the objects was investigated in vivo. The samples were implanted into rat muscular tissue and removed after different periods of exposure (3 days, 1, 2, 4, and 12 weeks after operation). It was shown that certain transformations in structure of the implanted carriers occurred over time, after which they underwent bioresorption. In 3 days after implantation, spherical vaterites degraded, and needle-like calcium carbonate objects were formed; during the following two weeks, these objects were completely resorbed in living tissues. Since no pathogenic influence of the samples on the surrounding tissues was revealed, we believe that СаСО3 vaterites covered with protective shells are safe for potential medicinal applications and can be recommended for further studies as target drug delivery systems.