Abstract
Three new metabolites, vibralactones D-F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of 1 was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound 1 showed weak inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (HSD) with IC50 values of 85.7 μM (human HSD1), 295.2 μM (mouse HSD1), and 87.1 μM (human HSD2). © 2010 Pharmaceutical Society of Japan.
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CITATION STYLE
Jiang, M. Y., Zhang, L., Dong, Z. J., Yang, Z. L., Leng, Y., & Liu, J. K. (2010). Vibralactones D-F from cultures of the basidiomycete Boreostereum vibrans. Chemical and Pharmaceutical Bulletin, 58(1), 113–116. https://doi.org/10.1248/cpb.58.113
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