Oxycodone in mastectomy surgery

Abstract

The pharmacological effects of oxycodone and morphine are close. The analgesic potency between oxycodone and morphine is presumed to have a 1:1 ratio. Fentanyl-to-morphine ratio was 1:100. The plasma levels of oxycodone are more active than morphine. The analgesic potency of oxycodone is about 30% greater than that of morphine and slightly longer acting than morphine. Oxycodone showed a longer duration of action and a better analgesic effect than fentanyl. Oxycodone could minimize patient hemodynamic responses to sudden stimuli such as endotracheal intubation, similar to fentanyl. A 41-year-old woman admitted to the hospital with elective surgery of mastectomy surgery. There was no complaint about the lump in mammae dextra. For the surgery, induction bolus of oxycodone 0.2 mg/kg was diluted with normal saline; for endotracheal intubation and postoperative, we used oxycodone with patient-controlled analgesia. Hemodynamic curves were within the normal limits, she had no complaints of postoperative nausea and vomiting or pruritus, and she was discharged on the 3 rd day.