Development and Evaluation of Gastro Retentive Mucoadhesive Microballoons of Esomeprazole to Treat Peptic Ulcer

Abstract

The Gastro-retentive medication delivery method may increase patient compliance by lowering drug plasma level fluctuations1. The absorption maxima (max) of esomeprazole magnesium in 0.1 N HCl solution were found to be at 291 nm. Correlation coefficient values better than 0.99 suggest that the calibration curves provide strong linearity data. The results showed that the medication was soluble in 0.1 N HCl and had the maximum solubility in water. Magnesium esomeprazole was found to have a partition coefficient of (0.2442). The prepared mucoadhesive microballons percentage yield was calculated, with a range of 88.2 to 96.5 percent. The shape and surface morphology of produced mucoadhesive microballons photographed using a scanning electron microscope. The effectiveness of drug entrapment was in the region of 81.71 % - 93.51 % . The swelling rate and percent mucoadhesion of Esomeprazole Magnesium mucoadhesive microballons ranged from 75.63 percent to 88.64 percent. The in-vitro buoyancy % of mucoadhesive microballons used to determine the floating ability of all formulations. All of the developed formulations were floated for at least 7 to 12 hours. The best formulations incorporate naturally occurring polysaccharide polymeric blends as Drug: HPMC: Carbopol 934 (1:1:1) that release more than 98.13 percent of the drug in a regulated and sustained manner in the stomach environment for up to 24 hours. Keywords:  Gastroretention, mucoadhesive microballoons, Esomeprazole, HPMC, Carbopol