Gonococcal antimicrobial resistance: 80 years in the making

Abstract

Antimicrobial resistance has been a problem for the treatment of gonorrhoea since the introduction of sulfa drugs in the 1930s. The gonococcus has a remarkable ability to obtain the genetic elements required to develop resistance and for these resistant strains to then widely disseminate. Many decades of antibiotic monotherapy have seen the introduction of a number of antibiotic classes herald a promising new era of treatment only to subsequently fail due to resistance development. The world is now faced with the prospect of extensively resistant Neisseria gonorrhoea and requires a coordinated action plan to detect and treat these resistant strains.