Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic?

Abstract

Uncontrolled inflammation giving rise toexcessive tissue inflammation can lead to chronic inflammation that enhancestissue destruction, amplifying many chronic human pathologies. Normally theacute inflammatory response is protective and should be self-limited returningtissues to functional homeostasis with endogenous programmed resolution vialeukocyte vasculature cell-cell interactions and crosstalk that biosynthesize pro-resolvingmediators. When failed resolution takes place, as with the use of NSAIDs, tissuesundergo chronic inflammation and fibrosis. Herein, we discuss these mechanismsand the role of specialized proresolving mediators, the resolvins, protectinsand maresins produced from essential omega-3 fatty acids EPA and DHA, and theircontributions via their cognate cell surface receptors, to the resolutionresponse. Harnessing these pathways and their cellular mechanisms can help inproviding new therapeutic approaches to many human diseases, infections, organprotection and trauma via resolution medicine to enhance the body’s ownresilience to challenge.