Kisspeptin/KISSIR system in breast cancer

Abstract

Kisspeptins (KP), peptide products of the kisspeptin-1 (KISSI) gene are the endogenous ligands for a G protein-coupled receptor (GPCR) - KP receptor (KISSIR). KISSIR couples to the Gaq/11 signaling pathway. KISSI is a metastasis suppressor gene and the KP/KISSIR signaling has anti-metastatic and tumor-suppressant effects in numerous human cancers. On the other hand, recent studies indicate that KP/KISSIR pathway plays detrimental roles in breast cancer. In this review, we summarize recent developments in the understanding of the mechanisms regulating KP/KISSIR signaling in breast cancer metastasis. © Ivyspring International Publisher.