Reactivation of chagas disease after autologous hematopoietic stem cell transplantation

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Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.




Chalela, C. M., Peña, A. M., Roa, A. M., Reyes, D. L., Rueda, J. P., Salazar, L. A., … Melo, C. L. S. (2021). Reactivation of chagas disease after autologous hematopoietic stem cell transplantation. Revista Da Sociedade Brasileira de Medicina Tropical, 54, 1–4.

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