Cannabinoid receptor type 2 agonist attenuates acute neurogenic pulmonary edema by preventing neutrophil migration after subarachnoid hemorrhage in rats

Abstract

Clinical- pathological analysis of fatal SAH showed that 70–90 % of deaths were associated with NPE [ 12 ,17 ], whereas only 31 % had clinically diagnosed NPE [ 17 ]. However, NPE after SAH continues to be a prevalent clinical problem with few effi cient pharmacological treatment options. Some studies have indicated that cannabinoid receptor type 2 (CB2R) activation plays important roles in preventing septic lung injury by attenuating neutrophil recruitment [ 16 ]. Since the infl ux of neutrophils can aggravate lung damage, inhibiting infi ltration of neutrophils by CB2R agonist may reduce NPE after SAH.