Impaired executive functions in experimental model of temporal lobe epilepsy

Abstract

Objective: The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder(ADHD-like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method: Male Wistar rats at 25 day of age were submitted toanimal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously videomonitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from60 days postnatal. Results: Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivityand impaired visuospatial working memory. Conclusion: Taken as a whole, we concluded that animals with TLE exhibited some cognitiveand behavioural changes consistent with ADHD-like behavior.