Abstract
Background: Among adult population, the osteoarthritis (OA) of knee is the major issue that can lead to pain, functional limitations, and reduced quality of life. Exercise therapy is a core component of management, yet the added value of core stability training in conjunction with kinetic chain exercises remains underexplored. Objective: To determine the effects of combined mode kinetic chain exercise with and without core stability training on pain, range of motion and quality of life in patients with knee OA. Methods: A total of 48 patients with osteoarthritis in their knees were the subjects of a randomized controlled experiment at PSRD Hospital in Lahore were randomly allocated to either Group B (kinetic chain exercise only) or Group A (kinetic chain exercise with core stability training) with 24 participants each. For 12 weeks, interventions were carried out three times a week. Quality of life (KOOS), knee range of motion (goniometry), and pain (NPRS) were evaluated at baseline, six weeks, and twelve weeks. Results: Group A and B both groups showed significant improvements in NPRS, ROM, and KOOS scores over time (p < 0.05). At 12 weeks, Group A demonstrated a greater reduction in pain compared to Group B (p = 0.002). Flexion ROM improved by 19.6° ± 3.2° in Group A versus 12.4° ± 2.9° in Group B (p < 0.001). KOOS total score increased by 34.8 ± 5.6 in Group A and 25.7 ± 5.1 in Group B (p < 0.001). Conclusion: Incorporating core stability exercises into a kinetic chain exercise program yields superior improvements in pain reduction, knee range of motion and quality of life in knee osteoarthritis patients compared to kinetic chain exercises alone. Trial registration: The study was registered at Clinical trial.gov and was submitted on 2024–04-18. Trial Registry number was NCT06377813.
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Maqsood, M., Sohail, J., & Batool, S. A. (2026). Combined mode-kinetic chain exercise with and without core stability exercises on patients with knee osteoarthritis. BMC Musculoskeletal Disorders, 27(1). https://doi.org/10.1186/s12891-026-09531-4
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