Hepatoprotective effects of polyherbal formulation against carbon tetrachloride-induced hepatic injury in albino rats: A toxicity screening approach

Abstract

Objective: To investigate the hepatoprotective activity of aqueous methanolic extract of polyherbal formulation and individual extracts of Calotropis procera, Gymnema sylvestre, and Lawsonia inermis leaves. Methods: The hepatoprotective activity of the formulation and extracts were assessed on the basis of histopathological changes in liver of carbon tetrachloride-induced hepatotoxic rats. Results: The result of present studies strongly indicates that the hepatoprotective property of polyherbal formulation as evidenced by less damaged hepatocytes cells. Conclusion: Polyherbal formulation revealed excellent hepatoprotective profile as compared to individual plants due to synergistic effect produced by different phytochemicals present in the formulation.