Correlation between Serum Galectin-3 Level with Wall Motion Score Index in Patients with ST-Segment Elevation Myocardial Infarction

Abstract

The inflammatory process plays an essential role in the process of atherosclerosis and the response of ventricular recovery after myocardial infarction. Galectin-3 is a mediator derived from macrophages and endothelium that is actively involved in various aspects of the inflammatory cell behavior. Galectin-3 increases in the formation of fibrosis and scar, which is a maladaptive response to injury and infarction such as ST-segment elevation myocardial infarction (STEMI). Wall Motion Score Index (WMSI) is a semiquantitative visual assessment of the dynamic left ventricular wall. WMSI has an association with left ventricular ejection fraction in assessing prognosis after myocardial infarction. This study aimed to determine the correlation of increasing galectin-3 level with WMSI in STEMI patients. A cross-sectional study with purposive sampling was done. Galectin-3 levels were measured using R&D System ELISA Quantikine® Human galectin-3 Immunoassay with units ng/ml. WMSI measured by 2D-echocardiography. We enrolled a total of 35 STEMI patients, 28 (80%) were males. The result of measurement of galectin-3 levels in STEMI patients increase significantly (12,545±6,504 ng/mL) and moderate positive correlation with WMSI (r=+0,429, p=0.01). The result of the study showed there is a significant positive correlation between serum galectin-3 level with WMSI in STEMI patients.