Intestinal histoplasmosis with Histoplasma duboisii in a patient infected by HIV-1 in Abidjan (Ivory Coast)

Abstract

We report a case of intestinal histoplasmosis with Histoplasma duboisii in a 39-year-old patient infected with HIV-1, admitted to the emergency department due to peritonitis with fever and weight loss. He underwent a right hemicolectomy, and the pre-perforation and ulcerated macroscopic aspect during surgery suggested a malignant tumor. The anatomopathological examination of the specimen removed revealed the presence of inflammatory granulomas containing Histoplasma duboisii yeasts. The evolution was rapidly unfavorable, culminating in the patient's death 12 days after treatment onset with intravenous amphotericin B associated with an antiseptic biantibiotherapy. The authors point out the rarity of intestinal localization of histoplasmosis in patients infected with HIV in Abidjan and the contribution of anatomopathological examination in the diagnosis of this condition. © 2011 Ehui E, et al.