Actividad acetilcolinesterasa (AChE) y butirilcolinesterasa (BUChE) en poblaciones mexicanas: Estudio piloto

Abstract

The analytical determination of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities is widely used in biological biomonitoring to evaluate exposure and detrimental effects caused by anticholinesterasic compounds. Nevertheless, a wide variability in values within the range considered as normal has been reported, which could be due to different factors. One of the most influencing factors on the variability of the data is the lack of standardized analytical and preanalytical parameters. The aim of this work was to know, under a consensual methodology, the intervals of AChE and BuChE activities in individuals non-occupationally exposed to anticholinesterase compounds from different states of the Mexican republic. From the participating laboratories, 22% reported values of AChE activity within the range considered as normal, whereas 67% reported values of BuChE activity within the range in a non-exposed population to anticholinesterase compounds. The results revealed an important variability in the values for AChE and BuChE activities, which show the need for continuous training among analysts and the homogenization of methodologies.