Japanese Source

Abstract

Dispersive liquid-liquid microextraction (DLLME) coupled gas chromatography mass spectrometry was applied to the determination of benzodiazepines (flunitrazepam and nimetazepam). Some important parameters, such as the kind of extraction and the disperser solvent, the volume of the disperser solvent and the extraction time were investigated. Using the optimum conditions of DLLME for benzodiazepines, tricyclic antidepressant drugs (amitriptyline and nortriptyline) and phenothiazines (chlorpromazine and promethazine) were extracted from aqueous samples. In addition, the DLLME technique was applied to the extraction of flunitrazepam from alcohol drink; simple and rapid extraction was possible. Thus, the DLLME technique is useful for the extraction of drugs in the forensic science field. © 2009 The Japan Society for Analytical Chemistry.