Synthesis of Finite Molecular Nanotubes by Connecting Axially Functionalized Macrocycles

Abstract

Monodispersed molecular nanotubes, particularly those with uniform lengths, are challenging targets for chemical synthesis. Here, we report the general design and efficient synthesis of finite molecular nanotubes, utilizing a dynamic assembly strategy to precisely stack axially functionalized macrocycles by chemical connections. Discrete tubular molecules, ranging from 7.8 to 19.8 kDa with covalent or coordinative connections, have been prepared from modular macrocyclic building blocks through highly convergent routes. The discrete molecular nature and structural anisotropy of these synthetic tubes warrant postsynthesis modifications and solution processing methods, as demonstrated by the controllable orientations when deposited onto different prefabricated surfaces.