Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related zinc-finger ZIM proteins

Abstract

The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8. Copyright © 2007 by the Genetics Society of America.