SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NEW ISATIN DERIVATIVES

Abstract

The indole and 7-azaindole derivatives both natural and synthetic have various pharmacological activities like antimicrobial, anticonvulsant, antioxidant, antidiabetic, MAO inhibitory and psychotropic activities. So it's a thought worthwhile to synthesis a series of new 7-AzaIsatin derivatives were synthesized by oxidising 7-azaindole followed by refluxing with p-amino ethyl benzoate, further treated with various alkyl halides to give (Z)-ethyl 4-(1substiuted-2-oxopyrrolo{[}2,3-b] pyridin-3-ylideneamino) benzoate derivatives. The structure and purity of the synthesized compounds was elucidated by spectral analysis (IR Mass, Elemental analysis and 1HNMR). These compounds were also screened for their in vitro antibacterial and antifungal activities by cup-plate method using Ampicillin and Clotimazole as standard drugs.