Evaluating the Risk Factors for Hospital-Onset Clostridium difficile Infections in a Large Healthcare System

Abstract

In this multicenter retrospective cohort study of over 1 million patients at 150 US hospitals, proton pump inhibitors increased the odds of a patient having hospital-onset Clostridium difcile infection as did third and fourth generation cephalosporins, carbapenems, and piperacillin/tazobactam. Tese fndings support appropriate prescribing of acid-suppression therapy and high-risk antibiotics.