Evaluation of the bolie model describing blood glucose response for the application to continuous subcutaneous insulin infusion

Abstract

In an attempt to develop an appropriate infusion program in a continuous subcutaneous insulin infusion system,a conventional pharmacodynamic model (the Bolie model) for describing the relationship between blood glucose and serum insulin levels was evaluated, using a depancreatized dog preparation. The Bolie model was found useful in estimatingthe basal insulin infusion rate. However, the model could not predict the serum insulin concentration-time profile required to maintain the postprandial blood glucose levels within a physiological range. It will be necessary to developamore appropriate model for determining the prandial subcutaneous insulin infusion rates in the continuous subcutaneousinsulin infusion system. © 1985, The Pharmaceutical Society of Japan. All rights reserved.